George beadle and edward tatum used mutant strains of neurospora to formulate the one-gene-one-enzyme hypothesis. researchers later updated this hypothesis to propose that one gene encodes one polypeptide because proteins can have multiple subunits. consider a heterotrimeric protein with all unique subunits. how many genes are required to form this protein?
A heterodimeric protein consists of two polypeptides (a polypeptide is a chain of amino acids) that differ in amino acid composition, number or order in the chain sequence. Each polypeptide makes a different subunit of the protein.
One gene encodes one polypeptide, so if the protein has two different polypeptides, two genes are required to form this protein.
some scientists like gregory adcock agree with thorne's theory of regional continuity.
others, like chris stringer and ian tattersall, believe thorne's results may be contaminated or misinterpreted.